ZFPM1

Zinc finger protein, FOG family member 1
PDB rendering based on 1srk.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XU7​
Identifiers
Symbols	ZFPM1 ; FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A
External IDs	OMIM: 601950 MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1 Gene
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor binding • RNA polymerase II activating transcription factor binding • DNA binding • protein binding • transcription factor binding • metal ion binding Cellular component • nucleus • nucleoplasm • transcription factor complex • cytoplasm • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • T-helper cell lineage commitment • outflow tract morphogenesis • atrioventricular valve morphogenesis • mitral valve formation • tricuspid valve formation • transcription, DNA-templated • heart development • blood coagulation • regulation of definitive erythrocyte differentiation • erythrocyte differentiation • megakaryocyte differentiation • platelet formation • granulocyte differentiation • negative regulation of protein binding • regulation of chemokine production • embryonic hemopoiesis • megakaryocyte development • positive regulation of interferon-gamma biosynthetic process • negative regulation of interleukin-4 biosynthetic process • negative regulation of fat cell differentiation • cardiac muscle tissue morphogenesis • definitive erythrocyte differentiation • primitive erythrocyte differentiation • negative regulation of mast cell differentiation • ventricular septum morphogenesis • atrial septum morphogenesis • transcriptional activation by promoter-enhancer looping Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	161882	22761
Ensembl	ENSG00000179588	ENSMUSG00000049577
UniProt	Q8IX07	O35615
RefSeq (mRNA)	NM_153813	NM_009569
RefSeq (protein)	NP_722520	NP_033595
Location (UCSC)	Chr 16: 88.45 – 88.54 Mb	Chr 8: 122.28 – 122.34 Mb
PubMed search

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG1) is a protein that in humans is encoded by the ZFPM1 gene.^[1] It is a cofactor of the GATA1 transcription factor.

References

1. "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Further reading

• Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.". Cell 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307.
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
• Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1.". Blood 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
• Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.". Blood 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
• Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
• Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis.". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
• Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.