ZFPM2

Zinc finger protein, FOG family member 2
Identifiers
Symbols	ZFPM2 ; DIH3; FOG2; SRXY9; ZC2HC11B; ZNF89B; hFOG-2
External IDs	OMIM: 603693 MGI: 1334444 HomoloGene: 8008 GeneCards: ZFPM2 Gene
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor binding • RNA polymerase II transcription coactivator activity • DNA binding • transcription corepressor activity • protein binding • transcription factor binding • zinc ion binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • vasculogenesis • in utero embryonic development • outflow tract septum morphogenesis • right ventricular cardiac muscle tissue morphogenesis • transcription, DNA-templated • gonadal mesoderm development • heart development • blood coagulation • cell differentiation • lung development • negative regulation of fat cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic organ development • ventricular septum morphogenesis • negative regulation of cell death • positive regulation of male gonad development • negative regulation of female gonad development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23414	22762
Ensembl	ENSG00000169946	ENSMUSG00000022306
UniProt	Q8WW38	Q8CCH7
RefSeq (mRNA)	NM_012082	NM_011766
RefSeq (protein)	NP_036214	NP_035896
Location (UCSC)	Chr 8: 104.59 – 105.8 Mb	Chr 15: 40.66 – 41.1 Mb
PubMed search

Zinc finger protein ZFPM2 is a protein that in humans is encoded by the ZFPM2 gene.^[1][2][3]

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.^[3]

Mutations in ZFPM2 cause Congenital Diaphragmatic Hernia .^[4]

Interactions

ZFPM2 has been shown to interact with GATA4,^[5] GATA1^[6] and CTBP2.^[2]

References

1. Svensson EC, Tufts RL, Polk CE, Leiden JM (Mar 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc Natl Acad Sci U S A 96 (3): 956–61. doi:10.1073/pnas.96.3.956. PMC 15332. PMID 9927675.
2. Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B (Sep 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J Biol Chem 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. PMID 10438528.
3. "Entrez Gene: ZFPM2 zinc finger protein, multitype 2".
4. Brady, P; Van Houdt, J; Callewaert, B; Deprest, J; Devriendt, K; Vermeesch, J. R. (2014). "Exome sequencing identifies ZFPM2 as a cause of familial isolated Congenital Diaphragmatic Hernia and possibly cardiovascular malformations". European Journal of Medical Genetics 57 (6): 247–52. doi:10.1016/j.ejmg.2014.04.006. PMID 24769157.
5. Svensson, E C; Tufts R L; Polk C E; Leiden J M (Feb 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3): 956–61. doi:10.1073/pnas.96.3.956. ISSN 0027-8424. PMC 15332. PMID 9927675.
6. Holmes, M; Turner J; Fox A; Chisholm O; Crossley M; Chong B (Aug 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. (UNITED STATES) 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. ISSN 0021-9258. PMID 10438528.

Further reading

• Fox AH, Liew C, Holmes M, et al. (1999). "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers.". EMBO J. 18 (10): 2812–22. doi:10.1093/emboj/18.10.2812. PMC 1171362. PMID 10329627.
• Crispino JD, Lodish MB, Thurberg BL, et al. (2001). "Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.". Genes Dev. 15 (7): 839–44. doi:10.1101/gad.875201. PMC 312667. PMID 11297508.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Anttonen M, Ketola I, Parviainen H, et al. (2004). "FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.". Biol. Reprod. 68 (4): 1333–40. doi:10.1095/biolreprod.102.008599. PMID 12606418.
• Pizzuti A, Sarkozy A, Newton AL, et al. (2004). "Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot.". Hum. Mutat. 22 (5): 372–7. doi:10.1002/humu.10261. PMID 14517948.
• Hirai M, Ono K, Morimoto T, et al. (2004). "FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes.". J. Biol. Chem. 279 (36): 37640–50. doi:10.1074/jbc.M401737200. PMID 15220332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chan EM, Comer EM, Brown FC, et al. (2005). "AML1-FOG2 fusion protein in myelodysplasia.". Blood 105 (11): 4523–6. doi:10.1182/blood-2004-07-2762. PMID 15705784.
• Ackerman KG, Herron BJ, Vargas SO, et al. (2005). "Fog2 is required for normal diaphragm and lung development in mice and humans.". PLoS Genet. 1 (1): 58–65. doi:10.1371/journal.pgen.0010010. PMC 1183529. PMID 16103912.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Finelli P, Pincelli AI, Russo S, et al. (2007). "Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis.". Clin. Genet. 71 (3): 195–204. doi:10.1111/j.1399-0004.2007.00752.x. PMID 17309641.
• Bleyl SB, Moshrefi A, Shaw GM, et al. (2007). "Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients.". Eur. J. Hum. Genet. 15 (9): 950–8. doi:10.1038/sj.ejhg.5201872. PMID 17568391.