ZFX

Zinc finger protein, X-linked
PDB rendering based on 5znf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 5znf​
Identifiers
Symbols	ZFX ; ZNF926
External IDs	OMIM: 314980 MGI: 99211 HomoloGene: 2561 GeneCards: ZFX Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • metal ion binding Cellular component • nucleoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • multicellular organismal development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7543	22764
Ensembl	ENSG00000005889	ENSMUSG00000079509
UniProt	P17010	P17012
RefSeq (mRNA)	NM_001178084	NM_001044386
RefSeq (protein)	NP_001171555	NP_001037851
Location (UCSC)	Chr X: 24.15 – 24.22 Mb	Chr X: 94.07 – 94.12 Mb
PubMed search

Zinc finger X-chromosomal protein is a protein that in humans is encoded by the ZFX gene.^[1]

References

1. "Entrez Gene: ZFX zinc finger protein, X-linked".

Further reading

• North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734.
• Mardon G, Luoh SW, Simpson EM, et al. (1990). "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.". Mol. Cell. Biol. 10 (2): 681–8. PMC 360866. PMID 2105457.
• Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts.". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929.
• Müller G, Schempp W (1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization.". Hum. Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
• Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1989). "ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation.". Cell 57 (7): 1247–58. doi:10.1016/0092-8674(89)90061-5. PMID 2500252.
• Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1990). "Putative transcription activator with alternative isoforms encoded by human ZFX gene.". Nature 342 (6250): 708–11. doi:10.1038/342708a0. PMID 2512506.
• Taylor DM, Ray PF, Ao A, et al. (1998). "Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage.". Mol. Reprod. Dev. 48 (4): 442–8. doi:10.1002/(SICI)1098-2795(199712)48:4<442::AID-MRD4>3.0.CO;2-Q. PMID 9364438.
• Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
• Poloumienko A (2004). "Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY.". Genome 47 (1): 74–83. doi:10.1139/g03-099. PMID 15060604.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.