ZFY

Zinc finger protein, Y-linked
PDB rendering based on 1klr.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1KLR​, 1KLS​, 1XRZ​, 5ZNF​, 7ZNF​
Identifiers
Symbols	ZFY ; ZNF911
External IDs	OMIM: 490000 HomoloGene: 88465 GeneCards: ZFY Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • metal ion binding Cellular component • nucleoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • multicellular organismal development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7544	n/a
Ensembl	ENSG00000067646	n/a
UniProt	P08048	n/a
RefSeq (mRNA)	NM_001145275	n/a
RefSeq (protein)	NP_001138747	n/a
Location (UCSC)	Chr Y: 2.94 – 2.98 Mb	n/a
PubMed search		n/a

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene.^[1][2]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.^[2]

References

1. Muller G, Schempp W (Jun 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum Genet 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
2. "Entrez Gene: ZFY zinc finger protein, Y-linked".

Further reading

• Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells". Arch. Med. Res. 32 (6): 553–8. doi:10.1016/S0188-4409(01)00317-4. PMID 11750730.
• Kochoyan M, Havel TF, Nguyen DT, et al. (1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition". Biochemistry 30 (14): 3371–86. doi:10.1021/bi00228a004. PMID 1849423.
• Kochoyan M, Keutmann HT, Weiss MA (1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition". Biochemistry 30 (29): 7063–72. doi:10.1021/bi00243a005. PMID 1854720.
• North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734.
• Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929.
• Affara NA, Chambers D, O'Brien J, et al. (1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9". Nucleic Acids Res. 17 (8): 2987–99. doi:10.1093/nar/17.8.2987. PMC 317707. PMID 2498838.
• Lau YF, Chan KM (1990). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues". Am. J. Hum. Genet. 45 (6): 942–52. PMC 1683462. PMID 2511751.
• Page DC, Mosher R, Simpson EM, et al. (1988). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell 51 (6): 1091–104. doi:10.1016/0092-8674(87)90595-2. PMID 3690661.
• Tricoli JV, Bracken RB (1993). "ZFY gene expression and retention in human prostate adenocarcinoma". Genes Chromosomes Cancer 6 (2): 65–72. doi:10.1002/gcc.2870060202. PMID 7680890.
• Erlandsson R, Wilson JF, Pääbo S (2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans". Mol. Biol. Evol. 17 (5): 804–12. doi:10.1093/oxfordjournals.molbev.a026359. PMID 10779541.
• Mittwoch U (2001). "Three thousand years of questioning sex determination". Cytogenet. Cell Genet. 91 (1–4): 186–91. doi:10.1159/000056842. PMID 11173854.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.