ZFYVE16

Zinc finger, FYVE domain containing 16
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3T7L​
Identifiers
Symbols	ZFYVE16 ; PPP1R69
External IDs	OMIM: 608880 MGI: 2145181 HomoloGene: 8826 GeneCards: ZFYVE16 Gene
Gene ontology Molecular function • protein binding • 1-phosphatidylinositol binding • phosphatidylinositol-3,4,5-trisphosphate binding • protein transporter activity • metal ion binding Cellular component • cytoplasm • early endosome • early endosome membrane • intracellular membrane-bounded organelle Biological process • protein targeting to lysosome • signal transduction • vesicle organization • endosomal transport • regulation of endocytosis • BMP signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9765	218441
Ensembl	ENSG00000039319	ENSMUSG00000021706
UniProt	Q7Z3T8	Q80U44
RefSeq (mRNA)	NM_001105251	NM_173392
RefSeq (protein)	NP_001098721	NP_775568
Location (UCSC)	Chr 5: 80.41 – 80.48 Mb	Chr 13: 92.49 – 92.53 Mb
PubMed search

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.^[1][2]

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM]^[2]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.^[3]

Interactions

ZFYVE16 has been shown to interact with TOM1.^[4]

References

1. Seet LF, Hong W (Nov 2001). "Endofin, an endosomal FYVE domain protein". J Biol Chem 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
2. "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
4. Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. (United States) 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

Further reading

• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Zhao BM, Hoffmann FM (2006). "Inhibition of Transforming Growth Factor-β1–induced Signaling and Epithelial-to-Mesenchymal Transition by the Smad-binding Peptide Aptamer Trx-SARA". Mol. Biol. Cell 17 (9): 3819–31. doi:10.1091/mbc.E05-10-0990. PMC 1556379. PMID 16775010.
• Chen YG, Wang Z, Ma J, et al. (2007). "Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling". J. Biol. Chem. 282 (13): 9688–95. doi:10.1074/jbc.M611704200. PMID 17272273.
• Chen Y, Low TY, Choong LY, et al. (2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516.