ZRSR2

Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
Identifiers
Symbols	ZRSR2 ; U2AF1-RS2; U2AF1L2; U2AF1RS2; URP; ZC3H22
External IDs	OMIM: 300028 MGI: 103287 HomoloGene: 21061 GeneCards: ZRSR2 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • pre-mRNA 3'-splice site binding • metal ion binding Cellular component • U12-type spliceosomal complex Biological process • spliceosomal complex assembly • mRNA splicing, via spliceosome • RNA splicing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8233	22184
Ensembl	ENSG00000169249	ENSMUSG00000031370
UniProt	Q15696	B1B0E8
RefSeq (mRNA)	NM_005089	NM_009453
RefSeq (protein)	NP_005080	NP_033479
Location (UCSC)	Chr X: 15.79 – 15.82 Mb	Chr X: 163.94 – 163.96 Mb
PubMed search

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.^[1][2][3][4]

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.^[4]

References

1. Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.
2. Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature 388 (6640): 397–400. doi:10.1038/41137. PMID 9237760.
3. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
4. "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

Further reading

• Brunner B, Todt T, Lenzner S, et al. (1999). "Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1.". Genome Res. 9 (5): 437–48. doi:10.1101/gr.9.5.437. PMC 310778. PMID 10330123.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.