ZS-9

ZS-9

Crystal structure of ZS-9. Blue spheres  =  oxygen atoms, red spheres  =  zirconium atoms, green spheres  =  silicon atoms.
Systematic (IUPAC) name
Silicic acid, sodium zirconium(4+) salt (3:2:1), hydrate
Clinical data
Routes of
administration		 Oral
Legal status
  • Investigational
Pharmacokinetic data
Bioavailability Not absorbed
Excretion Stool
Identifiers
CAS Number 242800-27-7
ATC code none
UNII D652ZWF066
Chemical data
Formula (2Na·H2O·3H4SiO4·H4ZrO6)n

ZS-9 (sodium zirconium cyclosilicate) is a selective oral sorbent that traps potassium ions throughout the gastrointestinal tract. It is being developed by ZS Pharma for the treatment of hyperkalemia (elevated serum potassium levels).[1]

Background

Main article: Hyperkalemia

Hyperkalemia occurs in 3 to 10% of hospitalized patients[2] but is often mild. Hyperkalemia can arise from impaired renal function, potassium-sparing diuretics and renin-angiotensin system blockers (e.g., ACE inhibitors, angiotensin receptor blockers, spironolactone) and diabetes mellitus.[2][3][4][5]

There is no universally accepted definition of what level of hyperkalemia is mild, moderate, or severe.[6] However, if hyperkalemia causes any ECG change it is considered a medical emergency[6] due to a risk of potentially fatal abnormal heart rhythms (arrhythmia) and is treated urgently.[6] serum potassium concentrations greater than 6.5 to 7.0 mmol/L in the absence of ECG changes are managed aggressively.[6]

Hyperkalemia, particularly if severe, is a marker for an increased risk of death.[2] However, there is disagreement regarding whether a modestly elevated serum potassium level directly causes significant problems. One viewpoint is that mild to moderate hyperkalemia is an secondary effect that denotes significant underlying medical problems.[2] Accordingly, these problems are both proximate and ultimate causes of death,[2] and adjustment of potassium may not be helpful. Alternatively, hyperkalemia may itself be an independent risk factor for cardiovascular mortality.[7]

Several approaches are used in treatment of hyperkalemia,.[6] In October 2015, the U.S. Food and Drug Administration (FDA) approved patiromer which works by binding free potassium ions in the gastrointestinal tract and releasing calcium ions for exchange. Previously, the only approved product was sodium polystyrene sulfonate (Kayexalate),[8] an organic ion-exchange resin that nonspecifically binds cations (e.g., calcium, potassium, magnesium) in the gastrointestinal tract. The effectiveness of sodium polystyrene sulfonate has been questioned: a study in healthy subjects showed that laxatives alone were almost as effective in increasing potassium secretion as laxatives plus Kayexalate.[9] In addition, use of sodium polystyrene sulfonate, particularly if formulated with high sorbitol content, is uncommonly but convincingly associated with colonic necrosis.[6][8][10][11]

Mechanism of action

Cross-sections of ZS-9 pores with three different ions (K⁺ = potassium, Na⁺ = sodium, Ca²⁺ = calcium). The specifity for potassium is thought to be caused by the diameter and composition of the pores, which resembles potassium channels.

ZS-9 is a zirconium silicate. Zirconium silicates have been extensively used in medical and dental applications because of their proven safety.[12] 11 zirconium silicates were screened by an iterative optimization process. ZS-9 selectively captures potassium ions, presumably by mimicking the actions of physiologic potassium channels.[13] ZS-9 is an inorganic cation exchanger crystalline with a high capacity to entrap monovalent cations, specifically potassium and ammonium ions, in the GI tract. ZS-9 is not systemically absorbed; accordingly, the risk of systemic toxicity may be minimized.

Clinical studies

A phase 2 clinical trial in 90 patients with chronic kidney disease and mild-to-moderate hyperkalemia found a significantly greater reduction in serum potassium with ZS-9 than placebo. ZS-9 was well tolerated, with a single adverse event (mild constipation).[14]

A double-blind, phase 3 clinical trial in 753 patients with hyperkalemia and underlying chronic kidney disease, diabetes, congestive heart failure, and in patients on renin-angiotensin system blockers compared ZS-9 with placebo.[15] Patients were randomly assigned to receive either ZS-9 (1.25g, 2.5g, 5g, or 10g) or placebo 3 times daily for 48 hours (acute phase). Patients who achieved normokalemia (serum potassium of 3.5-4.9 mmol/L) were randomly assigned to receive ZS-9 or placebo once daily for 12 additional days (maintenance phase). At the end of the acute phase, serum potassium significantly decreased in the 2.5g, 5g, and 10g ZS-9 groups. During the maintenance phase, once daily 5g or 10g ZS-9 maintained serum potassium at normal levels. Adverse events, including specifically gastrointestinal effects, were similar with either ZS-9 or placebo.[15]

A double-blind, phase 3 clinical trial in 258 patients with hyperkalemia and underlying chronic kidney disease, diabetes, congestive heart failure, and in patients on renin-angiotensin system blockers compared ZS-9 with placebo.[16] All patients received 10g ZS-9 three times daily for 48 hours in the initial open-label phase. Patients who achieved normokalemia (serum potassium 3.5-5.0mEq/L) were randomly assigned to receive either ZS-9 (5g, 10g, or 15g) or placebo once daily for 28 days (double-blind phase). 98% of patients (n=237) achieved normokalemia during the open-label phase. During the double-blind phase, once daily 5g, 10g, and 15g ZS-9 maintained serum potassium at normal levels in a significantly higher proportion of patients (80%, 90%, and 94%, respectively) than placebo (46%). Adverse events were generally similar with either ZS-9 or placebo. Hypokalemia occurred in more patients in the 10g and 15g ZS-9 groups (10% and 11%, respectively), versus none in the 5g ZS-9 or placebo groups.[16]

See also

References

  1. ↑ "ZS-9. A selective potassium binder". ZS-Pharma.
  2. 1 2 3 4 5 Elliott, M. J.; Ronksley, P. E.; Clase, C. M.; Ahmed, S. B.; Hemmelgarn, B. R. (2010). "Management of patients with acute hyperkalemia". Canadian Medical Association Journal 182 (15): 1631–5. doi:10.1503/cmaj.100461. PMC 2952010. PMID 20855477.
  3. ↑ Stevens, M. S.; Dunlay, R. W. (2000). "Hyperkalemia in hospitalized patients". International Urology and Nephrology 32 (2): 177–80. doi:10.1023/A:1007135517950. PMID 11229629.
  4. ↑ Navaneethan, S. D.; Yehnert, H.; Moustarah, F.; Schreiber, M. J.; Schauer, P. R.; Beddhu, S. (2009). "Weight Loss Interventions in Chronic Kidney Disease: A Systematic Review and Meta-analysis". Clinical Journal of the American Society of Nephrology 4 (10): 1565–74. doi:10.2215/CJN.02250409. PMID 19808241.
  5. ↑ Tamirisa, K. P.; Aaronson, K. D.; Koelling, T. M. (2004). "Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure". American Heart Journal 148 (6): 971–8. doi:10.1016/j.ahj.2004.10.005. PMID 15632880.
  6. 1 2 3 4 5 6 Taal, M.W.; Chertow, G.M.; Marsden, P.A.; Skorecki, K.; Yu, A.S.L.; Brenner, B.M. (2012). Brenner and Rector's The Kidney (Chapter 17, page 672, 9th ed.). Elsevier. ISBN 978-1-4160-6193-9.
  7. ↑ Fang, J.; Madhavan, S.; Cohen, H.; Alderman, M. H. (2000). "Serum potassium and cardiovascular mortality". Journal of General Internal Medicine 15 (12): 885–90. doi:10.1046/j.1525-1497.2000.91021.x. PMID 11119186.
  8. 1 2 Watson, M.; Abbott, K. C.; Yuan, C. M. (2010). "Damned if You Do, Damned if You Don't: Potassium Binding Resins in Hyperkalemia". Clinical Journal of the American Society of Nephrology 5 (10): 1723–6. doi:10.2215/CJN.03700410. PMID 20798253.
  9. ↑ Emmett, M.; Hootkins, R. E.; Fine, K. D.; Santa Ana, C. A.; Porter, J. L.; Fordtran, J. S. (1995). "Effect of three laxatives and a cation exchange resin on fecal sodium and potassium excretion". Gastroenterology 108 (3): 752–60. doi:10.1016/0016-5085(95)90448-4. PMID 7875477.
  10. ↑ Sterns, R. H.; Rojas, M.; Bernstein, P.; Chennupati, S. (2010). "Ion-Exchange Resins for the Treatment of Hyperkalemia: Are They Safe and Effective?". Journal of the American Society of Nephrology 21 (5): 733–5. doi:10.1681/ASN.2010010079. PMID 20167700.
  11. ↑ Kamel, K. S.; Schreiber, M. (2012). "Asking the question again: Are cation exchange resins effective for the treatment of hyperkalemia?". Nephrology Dialysis Transplantation 27 (12): 4294–7. doi:10.1093/ndt/gfs293. PMID 22989741.
  12. ↑ Denry I, Kelly JR. State of the art of zirconia for dental applications. Dental Materials. Volume 24, Issue 3, March 2008, Pages 299–307
  13. ↑ =Stavros, F (2014). "Characterization of Structure and Function of ZS-9, a K⁺ Selective Ion Trap". PLOS ONE 9 (12): e114686. doi:10.1371/journal.pone.0114686. PMID 25531770.
  14. ↑ Ash SR, et al. "Safety and efficacy of ZS-9, a novel selective cation trap, for treatment of hyperkalemia in CKD patients." American Society of Nephrology 2013 conference, Late-Breaking Abstract.
  15. 1 2 Packham DK, et al. (2014). "Sodium zirconium cyclosilicate in hyperkalemia". New England Journal of Medicine 372 (3): 222–31. doi:10.1056/NEJMoa1411487. PMID 25415807.
  16. 1 2 Kosiborod M, et al. (2014). "Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia". Journal of the American Medical Association 312 (21): 2223–33. doi:10.1001/jama.2014.15688. PMID 25402495.
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