Zardaverine

Zardaverine
Names

IUPAC name 3-[4-(Difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one
Identifiers
CAS Number	101975-10-4
ChemSpider	5521
Jmol 3D image	Interactive graph
PubChem	5723
InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) Key: HJMQDJPMQIHLPB-UHFFFAOYSA-N
SMILES COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F
Properties
Chemical formula	C₁₂H₁₀F₂N₂O₃
Molar mass	268.22 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Zardaverine is a phosphodiesterase inhibitor.^[1]

References

↑ Kümmerle, AE; Schmitt, M; Cardozo, SV; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CA; Bourguignon, JJ; Barreiro, EJ (2012). "Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors". Journal of Medicinal Chemistry 55 (17): 7525–45. doi:10.1021/jm300514y. PMID 22891752.

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