(2Z,6Z)-farnesyl diphosphate synthase

(2Z,6Z)-farnesyl diphosphate synthase (EC 2.5.1.92, cis,cis-farnesyl diphosphate synthase, Z,Z-FPP synthase, zFPS, Z,Z-farnesyl pyrophosphate synthase) is an enzyme with systematic name dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units).^[1] This enzyme catalyses the following chemical reaction

dimethylallyl diphosphate + 2 isopentenyl diphosphate

\rightleftharpoons

2 diphosphate + (2Z,6Z)-farnesyl diphosphate

This enzyme was originally characterized from wild tomato.

References

↑ Sallaud, C., Rontein, D., Onillon, S., Jabes, F., Duffe, P., Giacalone, C., Thoraval, S., Escoffier, C., Herbette, G., Leonhardt, N., Causse, M. and Tissier, A. (2009). "A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites". Plant Cell 21: 301–317. doi:10.1105/tpc.107.057885. PMID 19155349.

External links

(2Z,6Z)-farnesyl diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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