(R)-Perdesonide
-Perdesonide.png) | |
-Perdesonide_ball-and-stick.png) Ball and stick structure of (R)-isomer of perdesonide | |
| Systematic (IUPAC) name | |
|---|---|
|
(((2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,12bS)-2,6b-Difluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one | |
| Identifiers | |
| CAS Number | 83603-33-2 |
| Chemical data | |
| Formula | C25H32F2O6 |
| Molar mass | 466.52 g·mol−1 |
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(R)-Perdesonide is one of the two isomers of perdesonide, a glucocorticoid steroid. There is a dioxolane moiety with a chiral carbon at position 3; this was introduced to reduce mineralocorticoid activity. The (R)-isomer of the acetal has been shown to be the most potent in this class of steroid. Perdesonide resembles clocortolone in that both have two halide atoms; perdesonide has two fluorine atoms and clocortolone has one chlorine atom and one fluorine atom.[1]
See also
References
- ↑ “Foye's Principles of Medicinal Chemistry”
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