Perdesonide
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| Systematic (IUPAC) name | |
|---|---|
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(2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one | |
| Identifiers | |
| CAS Number | 51333-19-8 |
| Chemical data | |
| Formula | C25H32F2O6 |
| Molar mass | 466.51 g/mol |
  (what is this?) (verify) | |
Perdesonide is a glucocorticoid steroid. It is closely related to budesonide and differs by having a difluorinated steroid skeleton. The introduction of the 2 fluorines to the steroid skeleton was shown to increase systemic activity to a greater degree than local activity.[1] Perdesonide resembles clocortolone in that both have two halide atoms; perdesonide has two fluorine atoms and clocortolone has one chlorine atom and one fluorine atom.[2] Perdesonide is racemic at the carbon of the acetal. The R-isomer of the acetal as in (R)-Perdesonide is more active.
See also
References
External links
- , Drug Development of Inhaled Steroids: A Pharmacologist's View Based on Experiences from the Budesonide Project
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