(R)-citramalate synthase
(R)-citramalate synthase (EC 2.3.1.182, CimA) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- acetyl-CoA + pyruvate + H2O
CoA + (2R)-2-hydroxy-2-methylbutanedioate
This enzyme participates in a novel pyruvate pathway for isoleucine biosynthesis.
References
- ↑ Howell, D.M., Xu, H. and White, R.H. (1999). "(R)-Citramalate synthase in methanogenic archaea". J. Bacteriol. 181: 331–333. PMID 9864346.
- ↑ Xu, H., Zhang, Y., Guo, X., Ren, S., Staempfli, A.A., Chiao, J., Jiang, W. and Zhao, G. (2004). "Isoleucine biosynthesis in Leptospira interrogans serotype 1ai strain 56601 proceeds via a threonine-independent pathway". J. Bacteriol. 186: 5400–5409. doi:10.1128/jb.186.16.5400-5409.2004. PMID 15292141.
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