(R)-citramalate synthase

(R)-citramalate synthase
Identifiers
EC number 2.3.1.182
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(R)-citramalate synthase (EC 2.3.1.182, CimA) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + pyruvate + H2O \rightleftharpoons CoA + (2R)-2-hydroxy-2-methylbutanedioate

This enzyme participates in a novel pyruvate pathway for isoleucine biosynthesis.

References

  1. Howell, D.M., Xu, H. and White, R.H. (1999). "(R)-Citramalate synthase in methanogenic archaea". J. Bacteriol. 181: 331–333. PMID 9864346.
  2. Xu, H., Zhang, Y., Guo, X., Ren, S., Staempfli, A.A., Chiao, J., Jiang, W. and Zhao, G. (2004). "Isoleucine biosynthesis in Leptospira interrogans serotype 1ai strain 56601 proceeds via a threonine-independent pathway". J. Bacteriol. 186: 5400–5409. doi:10.1128/jb.186.16.5400-5409.2004. PMID 15292141.

External links

This article is issued from Wikipedia - version of the Thursday, March 31, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.