(S)-N-acetyl-1-phenylethylamine hydrolase

(S)-N-acetyl-1-phenylethylamine hydrolase
Identifiers
EC number	3.5.1.85
CAS number	192230-94-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a (S)-N-acetyl-1-phenylethylamine hydrolase (EC 3.5.1.85) is an enzyme that catalyzes the chemical reaction

N-acetylphenylethylamine + H₂O $\rightleftharpoons$ phenylethylamine + acetate

Thus, the two substrates of this enzyme are N-acetylphenylethylamine and H₂O, whereas its two products are phenylethylamine and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (S)-N-acetylphenylethylamine:H₂O hydrolase. At least one compound, Phenylmethanesulfonylfluoride is known to inhibit this enzyme.

References

• Brunella A, Graf M, Kittelmann M, Lauma K and Ghisalba O (1997). "Production, purification, and characterization of a highly enantioselective (S)-N-acetyl-1-phenylethyl amidohydrolase from Rhodococcus". Appl. Microbiol. Biotechnol. 47 (5): 515–520. doi:10.1007/s002530050965.