(Myelin basic protein)-arginine N-methyltransferase

[myelin basic protein]-arginine N-methyltransferase
Identifiers
EC number	2.1.1.126
CAS number	9055-07-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a [myelin basic protein]-arginine N-methyltransferase (EC 2.1.1.126) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [myelin basic protein]-arginine $\rightleftharpoons$ S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-arginine

Thus, the two substrates of this enzyme are S-adenosyl methionine and myelin basic protein-arginine, whereas its two products are S-adenosylhomocysteine and myelin basic protein-Nomega-methyl-arginine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[myelin-basic-protein]-arginine Nomega-methyltransferase. Other names in common use include myelin basic protein methylase I, protein methylase I, S-adenosyl-L-methionine:[myelin-basic-protein]-arginine, and omega-N-methyltransferase.

References

• Ghosh SK, Paik WK, Kim S (1988). "Purification and molecular identification of two protein methylases I from calf brain. Myelin basic protein- and histone-specific enzyme". J. Biol. Chem. 263 (35): 19024–33. PMID 2461933.