1,3-Difluoro-2-propanol

1,3-Difluoro-2-propanol

Names
IUPAC name 1,3-Difluoro-2-propanol
Identifiers
CAS Number	453-13-4
ChemSpider	61300
Jmol interactive 3D	Image Image
PubChem	67985
InChI InChI=1S/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2 Key: PVDLUGWWIOGCNH-UHFFFAOYSA-N InChI=1/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2 Key: PVDLUGWWIOGCNH-UHFFFAOYAJ
SMILES OC(CF)CF FCC(O)CF
Properties
Chemical formula	C3H6F2O
Molar mass	96.08 g·mol^−1
Density	1.24 g/cm^3 (at 25 °C) [1]
Boiling point	54 to 55 °C (129 to 131 °F; 327 to 328 K)
Hazards
Flash point	42 °C (108 °F; 315 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1,3-Difluoro-2-propanol is a metabolic poison which disrupts the citric acid cycle and is used as a rodenticide, similar to sodium fluoroacetate. It is the main ingredient (along with 1-chloro-3-fluoro-2-propanol) in the rodenticide product Gliftor which was widely used in the former USSR.^[2][3][4]

References

1. Sigma Aldrich
2. Buklan AI, Kravets AF (1986). "[Gliftor poisoning]". Sud. Med. Ekspert. (in Russian) 29 (1): 55–6. PMID 3961873.
3. Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ (1998). "The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote". J. Biochem. Mol. Toxicol. 12 (1): 41–52. doi:10.1002/(SICI)1099-0461(1998)12:1<41::AID-JBT6>3.0.CO;2-P. PMID 9414486.
4. Menon KI, Feldwick MG, Noakes PS, Mead RJ (2001). "The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (−)-erythro-fluorocitrate". J. Biochem. Mol. Toxicol. 15 (1): 47–54. doi:10.1002/1099-0461(2001)15:1<47::AID-JBT6>3.0.CO;2-E. PMID 11170315.