1,5-anhydro-D-fructose reductase

1,5-anhydro-D-fructose reductase
Identifiers
EC number	1.1.1.263
CAS number	206138-19-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) is an enzyme that catalyzes the chemical reaction

1,5-anhydro-D-glucitol + NADP⁺ $\rightleftharpoons$ 1,5-anhydro-D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are 1,5-anhydro-D-glucitol and NADP⁺, whereas its 3 products are 1,5-anhydro-D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP⁺ oxidoreductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GLX.

References

• Sakuma M, Kametani S and Akanuma H. "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose". J. (Tokyo). Biochem. (1): 189–193. PMID 9504428.