1450s in architecture
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Buildings and structures 
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| 1440s . 1450s in architecture . 1460s | 
| Architecture timeline | 
Events
- 1452 - Leon Battista Alberti completes writing De Re Aedificatoria
 
Buildings
- 1450 - Reconstruction of Sforza Castle in Milan as a palace begun
 - 1451–1457 - Villa Medici in Fiesole, Tuscany, designed by Michelozzo or Leon Battista Alberti, built
 - c.1451 - Palazzo Rucellai in Florence, probably designed by Leon Battista Alberti and executed, at least in part, by Bernardo Rossellino, substantially completed
 - 1452 - Hospices de Beaune in France, probably designed by Jacques Wiscrère, opened
 - 1456 - Ospedale Maggiore in Milan begun by Filarete
 - 1457 - Edo Castle in Japan first fortified by Ōta Dōkan
 - 1458 - Pitti Palace in Florence begun by Bartolommeo Ammanati and perhaps Brunelleschi
 - Approximate date? - Palazzo Pisani Moretta on the Grand Canal (Venice) built
 
Births
- 1450: Bartolomeo Montagna, Italian painter and architect (died 1523)
 - 1452: April 15 - Leonardo da Vinci, Italian polymath (died 1519)
 - c.1456: Bramantino, born Bartolomeo Suardi, Milanese painter and architect (died c.1530)
 
Deaths
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