16S rRNA (cytosine967-C5)-methyltransferase
16S rRNA (cytosine967-C5)-methyltransferase (EC 2.1.1.176, rsmB (gene), fmu (gene), 16S rRNA m5C967 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine967-C5)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + cytosine967 in 16S rRNA
S-adenosyl-L-homocysteine + 5-methylcytosine967 in 16S rRNA
The enzyme specifically methylates cytosine967 at C5 in 16S rRNA.
References
- ↑ Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. (1999). "Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli". Biochemistry 38: 1884–1892. doi:10.1021/bi981880l. PMID 10026269.
- ↑ Gu, X.R., Gustafsson, C., Ku, J., Yu, M. and Santi, D.V. (1999). "Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli". Biochemistry 38: 4053–4057. doi:10.1021/bi982364y. PMID 10194318.
- ↑ Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D. and Stroud, R.M. (2003). "The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate". Structure 11: 1609–1620. doi:10.1016/j.str.2003.10.014. PMID 14656444.
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