16S rRNA (guanine1207-N2)-methyltransferase
16S rRNA (guanine1207-N2)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine1207 in 16S rRNA
S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA.
References
- ↑ Tscherne, J.S., Nurse, K., Popienick, P. and Ofengand, J. (1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli". J. Biol. Chem. 274: 924–929. doi:10.1074/jbc.274.2.924. PMID 9873033.
- ↑ Sunita, S., Purta, E., Durawa, M., Tkaczuk, K.L., Swaathi, J., Bujnicki, J.M. and Sivaraman, J. (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC". Nucleic Acids Res. 35: 4264–4274. doi:10.1093/nar/gkm411. PMID 17576679.
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