16S rRNA (guanine527-N7)-methyltransferase
16S rRNA (guanine527-N7)-methyltransferase (EC 2.1.1.170, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine527-N7)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine527 in 16S rRNA
S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
The enzyme specifically methylates guanine527 at N7 in 16S rRNA.
References
- ↑ Okamoto, S., Tamaru, A., Nakajima, C., Nishimura, K., Tanaka, Y., Tokuyama, S., Suzuki, Y. and Ochi, K. (2007). "Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria". Mol. Microbiol. 63: 1096–1106. doi:10.1111/j.1365-2958.2006.05585.x. PMID 17238915.
- ↑ Romanowski, M.J., Bonanno, J.B. and Burley, S.K. (2002). "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold". Proteins 47: 563–567. doi:10.1002/prot.10121.abs. PMID 12001236.
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