18-Hydroxycorticosterone

18-Hydroxycorticosterone
Identifiers


CAS Number	561-65-9^N
ChEBI	CHEBI:16485^Y
ChemSpider	10748^Y
Jmol interactive 3D	Image
MeSH	18-hydroxycorticosterone
PubChem	11222
InChI InChI=1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1^Y Key: HFSXHZZDNDGLQN-ZVIOFETBSA-N^Y InChI=1/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1 Key: HFSXHZZDNDGLQN-ZVIOFETBBO
SMILES O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@H](C(=O)CO)CC[C@H]3[C@@H]1CC2)CO)(C)CC4
Properties
Chemical formula	C₂₁H₃₀O₅
Molar mass	362.46 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

18-Hydroxycorticosterone is a derivative of corticosterone.

It serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa:

Corticosteroid biosynthetic pathway in rat

References

Mineralocorticoid signaling

Receptor
(ligands)

Agonists	11-Deoxycorticosterone (desoxycortone) 11-Deoxycortisol (cortodoxone) 16α,18-Dihydroxy-11-deoxycorticosterone 17-Hydroxyaldosterone 18-Hydroxy-11-deoxycorticosterone 19-Norprogesterone Aldosterone Corticosterone Desoxycortone acetate Desoxycortone enanthate Desoxycortone glucoside Desoxycortone pivalate Hydrocortisone (cortisol) Fludrocortisone Fludrocortisone acetate Mometasone furoate Prednisolone Prednisone

Antagonists	3α-Hydroxytibolone 3β-Hydroxytibolone 6β-Hydroxy-7α-thiomethylspironolactone 7α-Thiomethylspironolactone 17-Hydroxyprogesterone Amlodipine Benidipine BR-4628 Canrenoate potassium (potassium canrenoate) Canrenoic acid Canrenone Dicirenone Drospirenone Eplerenone Felodipine Finerenone Gestodene Guggulsterone Mespirenone Mexrenoate potassium Mexrenoic acid Mexrenone Nifedipine Nimodipine Nitrendipine Oxprenoic acid Oxprenoate potassium (RU-28318) PF-03882845 Pregnenolone Progesterone Prorenoate potassium Prorenoic acid (prorenoate) Prorenone RU-26752 SC-5233 SC-8109 SM-368229 Spirorenone Spironolactone Spiroxasone Tibolone

Enzyme

Modulators	See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).

Others

Precursors	Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone Pregnenolone sulfate 17-Hydroxypregnenolone Progesterone 17-Hydroxyprogesterone 11-Deoxycorticosterone 18-Hydroxydeoxycorticosterone Corticosterone 18-Hydroxycorticosterone

Indirect	ACTH (corticotropin) CRH Plasma proteins (albumin, transcortin) Vasopressin

See also: Androgenics • Estrogenics • Glucocorticoids • Progestogenics

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