Prorenone

Prorenone
Systematic (IUPAC) name
(1aS,5aR,5bS,7aS,8R,10aS,10bR,10cS)-5a,7a-Dimethyl-1,1a,3',4,4',5,5a,5b,6,7,7a,9,10,10a,10b,10c-hexadecahydro-3H,5'H-spiro[cyclopenta[a]cyclopropa[l]phenanthrene-8,2'-furan]-3,5'-dione
Identifiers
CAS Number 49848-04-6
PubChem CID 170819
IUPHAR/BPS 2876
DrugBank DB00700
ChemSpider 149344
Synonyms 3-(17β-Hydroxy-6β,7β-methylene-3-oxo-4-androsten-17α-yl)propionic acid γ-lactone
Chemical data
Formula C23H30O3
Molar mass 354.48 g/mol

Prorenone (code names SC-23133, AC1L56BB) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed.

Chemical synthesis

Prorenone can be synthesized via a Johnson–Corey–Chaykovsky reaction by reaction of canrenone with trimethylsulfonium iodide and sodium hydride.[1]

See also

References

  1. Chinn, L.; 1974, U.S. Patent 3,845,041



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