Clofenamide

Clofenamide
Systematic (IUPAC) name


4-chlorobenzene-1,3-disulfonamide
Identifiers
CAS Number	671-95-4^Y
ATC code	C03BA07 (WHO)
PubChem	CID 69594
ChemSpider	62797^Y
UNII	582ILN204B^Y
KEGG	D01822^Y
ChEMBL	CHEMBL1865258^N
Chemical data
Formula	C₆H₇ClN₂O₄S₂
Molar mass	270.714 g/mol
SMILES O=S(=O)(c1cc(ccc1Cl)S(=O)(=O)N)N
InChI InChI=1S/C6H7ClN2O4S2/c7-5-2-1-4(14(8,10)11)3-6(5)15(9,12)13/h1-3H,(H2,8,10,11)(H2,9,12,13)^Y Key:NENBAISIHCWPKP-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Clofenamide (or diumide) is a low-ceiling sulfonamide diuretic.

References

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozoline Muzolimine Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Osmotic diuretics (PT, DL)

Vasopressin receptor inhibitors
(DCT and CD)

Other

Ethanol, Isopropanol, 2M2B
mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
Theobromine
Cicletanine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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