Polythiazide

Polythiazide
Systematic (IUPAC) name


6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601101
Identifiers
CAS Number	346-18-9^Y
ATC code	C03AA05
PubChem	CID 4870
IUPHAR/BPS	7274
ChemSpider	4704^N
UNII	36780APV5N^N
KEGG	D00657^N
ChEMBL	CHEMBL1587^N
Chemical data
Formula	C₁₁H₁₃ClF₃N₃O₄S₃
Molar mass	439.88 g/mol
^NY (what is this?) (verify)

Polythiazide is a thiazide diuretic.^[1]^[2] A diuretic is any substance that promotes the production of urine.

References

↑ O'Brien, E. T.; MacKinnon, J. (1972). "Propranolol and polythiazide in treatment of hypertension". British heart journal 34 (10): 1042–1044. doi:10.1136/hrt.34.10.1042. PMC 458544. PMID 5086971.
↑ Monroy, A.; Plata, C.; Hebert, S. C.; Gamba, G. (2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction". American Journal of Physiology. Renal Physiology 279 (1): F161–F169. PMID 10894798.

Symporter inhibitors

Sodium chloride	thiazide: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide other: Chlorthalidone Metolazone

Sodium, potassium, chloride	Bumetanide Furosemide

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozoline Muzolimine Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Osmotic diuretics (PT, DL)

Vasopressin receptor inhibitors
(DCT and CD)

Other

Ethanol, Isopropanol, 2M2B
mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
Theobromine
Cicletanine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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