Bendroflumethiazide

Bendroflumethiazide
Systematic (IUPAC) name
3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com Consumer Drug Information
Pregnancy
category
Routes of
administration
Oral
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability 100%
Protein binding 96%
Metabolism extensive
Biological half-life 3-4 hours[2]
Identifiers
CAS Number 73-48-3 YesY
ATC code C03AA01 (WHO)
PubChem CID 2315
IUPHAR/BPS 7122
DrugBank DB00436 YesY
ChemSpider 2225 YesY
UNII 5Q52X6ICJI YesY
KEGG D00650 YesY
ChEBI CHEBI:3013 YesY
ChEMBL CHEMBL1684 YesY
Chemical data
Formula C15H14F3N3O4S2
Molar mass 421.415 g/mol
  (verify)

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Adverse effects

Common adverse effects:[3]

Rare adverse effects:[4]

Alcohol

Bendroflumethiazide is known to have an adverse interaction with alcohol. It is advised that those using this diuretic should abstain from alcohol consumption during use, as it is possible to experience a sudden drop in blood pressure, especially if standing up.

Other considerations

Bendroflumethiazide should not be used by pregnant women, or women who have just given birth. Due to the nature of the medication, it is possible for it to pass into the breast milk and consequently to the child. It is also known that bendroflumethiazide suppresses the production of breast milk. Pregnant or lactating women with hypertension may need to discuss with their prescriber as to which alternative treatment may be more suitable. Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving.[5]

References


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