Clorexolone

Clorexolone
Systematic (IUPAC) name

6-chloro-2-cyclohexyl-3-oxo-2,3-dihydro- 1H-isoindole-5-sulfonamide
Identifiers
CAS Number	2127-01-7
ATC code	C03BA12 (WHO)
PubChem	CID 16473
ChemSpider	15615
UNII	Q2PLT3FS05^Y
KEGG	D01436
ChEMBL	CHEMBL2106167
Chemical data
Formula	C₁₄H₁₇ClN₂O₃S
Molar mass	328.814 g/mol
SMILES O=S(=O)(c1cc2C(=O)N(Cc2cc1Cl)C3CCCCC3)N

Clorexolone is a low-ceiling sulfonamide diuretic.

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozoline Muzolimine Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Osmotic diuretics (PT, DL)

Vasopressin receptor inhibitors
(DCT and CD)

Other

Ethanol, Isopropanol, 2M2B
mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
Theobromine
Cicletanine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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