Norethandrolone

Norethandrolone
Systematic (IUPAC) name
(17β)-17-ethyl-17-hydroxyester-4-en-3-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Identifiers
CAS Number 52-78-8
ATC code A14AA09 (WHO)
PubChem CID 5858
ChemSpider 5649 YesY
UNII P7W01638W6 YesY
KEGG D07127 YesY
Synonyms Noretandrolone; CB-8022
Chemical data
Formula C20H30O2
Molar mass 302.451 g/mol
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Norethandrolone (INN, BAN) (brand names Nilevar, Pronabol), also known as 17α-ethyl-19-nortestosterone, is an anabolic steroid.[1] It was synthesized at G. D. Searle & Company in 1953 and was originally studied as a progestin, along with norethisterone and noretynodrel, but was ultimately not marketed as such.[2][3] In 1955, it was re-examined for testosterone-like activity and was found to have similar anabolic activity to testosterone but only one-sixteenth the androgenic potency.[3][4] The drug was introduced in the United States as an anabolic steroid in 1965 under the trade name Nilevar[5] but was withdrawn from the market in the 1980s due to concerns of cholestatic jaundice.[4] Norethandrolone is now only marketed in Australia, France, and Switzerland, and as with all 17α-alkylated oral steroids, long-term use in high doses may result in elevated liver enzymes and consequently cirrhosis.[6] It is used in the treatment of muscle wasting,[4] patients with severe burns, after severe trauma, and for certain forms of aplastic anemia.

See also

References

  1. ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 885–. ISBN 978-1-4757-2085-3.
  2. ↑ Nicolae Sfetcu (2 May 2014). Health & Drugs: Disease, Prescription & Medication. Nicolae Sfetcu. pp. 1051–. GGKEY:JPFE1Q59083.
  3. 1 2 Charles D. Kochakian (6 December 2012). Anabolic-Androgenic Steroids. Springer Science & Business Media. pp. 380–. ISBN 978-3-642-66353-6.
  4. 1 2 3 Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 206–. ISBN 978-0-471-89979-2.
  5. ↑ W., Llewellyn. (2005). Anabolics. p. 156.
  6. ↑ D., Lednicer. (2011). Steroid Chemistry at Glance. Wiley. p. 67.



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