Dimethisterone

Dimethisterone

Names
IUPAC name (6S,8R,9S,10R,13S,14S,17S)-17-hydroxy-6,10,13-trimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Other names Dimethindrone
Identifiers
CAS Number	79-64-1
ChemSpider	6357
Jmol interactive 3D	Image
PubChem	6607
UNII	OIC9M646C5
InChI InChI=1S/C23H32O2/c1-5-9-23(25)12-8-19-17-13-15(2)20-14-16(24)6-10-21(20,3)18(17)7-11-22(19,23)4/h14-15,17-19,25H,6-8,10-13H2,1-4H3/t15-,17+,18-,19-,21+,22-,23-/m0/s1 Key: LVHOURKCKUYIGK-RGUJTQARSA-N InChI=1/C23H32O2/c1-5-9-23(25)12-8-19-17-13-15(2)20-14-16(24)6-10-21(20,3)18(17)7-11-22(19,23)4/h14-15,17-19,25H,6-8,10-13H2,1-4H3/t15-,17+,18-,19-,21+,22-,23-/m0/s1 Key: LVHOURKCKUYIGK-RGUJTQARBC
SMILES CC#C[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C)C)O
Properties
Chemical formula	C23H32O2
Molar mass	340.50 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dimethisterone (INN, USAN, BAN) (brand names Lutagan, Secrosteron), also known as 6α,21-dimethylethisterone, is a steroidal progestin that is used as a hormonal contraceptive in combination with high doses of ethinyl estradiol (100 mcg) under the brand name Oracon.^[1][2][3][4] It is a relatively weak progestin,^[3] in fact, one of the weakest known,^[2] and unlike ethisterone,^[5] has no androgenic effects in animals even at very high dosages.^[6] Dimethisterone was introduced in the United States as Oracon in 1965.^[7]

See also

• Norethisterone

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 430–. ISBN 978-1-4757-2085-3.
2. Rodolfo Paoletti; N. Pasetto; J.L. Ambrus (6 December 2012). The Menopause and Postmenopause: The Proceedings of an International Symposium held in Rome, June 1979. Springer Science & Business Media. pp. 374–. ISBN 978-94-011-7230-1.
3. Earl A. Surwit; David Alberts (6 December 2012). Endometrial Cancer. Springer Science & Business Media. pp. 11–. ISBN 978-1-4613-0867-6.
4. Richard Patterson (21 December 2012). Drugs in Litigation: Damage Awards Involving Prescription and Nonprescription Drugs. LexisNexis. pp. 483–484. ISBN 978-0-327-18698-4.
5. Richard M. Eglen; Mont R. Juchau; Gillian Edwards; Arthur H. Weston; Helen Wise; M. D. Murray; D. Craig Brater; Olivier Valdenaire; Philippe Vernier; Annemarie Polak (6 December 2012). Progress in Drug Research: Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser. pp. 72–. ISBN 978-3-0348-8863-9.
6. JUCKER (8 March 2013). Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques. Birkhäuser. pp. 166–. ISBN 978-3-0348-7053-5.
7. William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1331–. ISBN 978-0-8155-1856-3.