Trimegestone

Trimegestone

Systematic (IUPAC) name
(8S,13S,14S,17S)-17-[(2S)-2-hydroxypropanoyl]-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Identifiers
CAS Number	74513-62-5
ATC code	G03FA16 (WHO)
PubChem	CID 68926
ChemSpider	62152
Synonyms	RU-27987
Chemical data
Formula	C22H30O3
Molar mass	342.472 g/mol
SMILES C[C@@H](C(=O)[C@]1(CC[C@@H]2[C@@]1(CCC3=C4CCC(=O)C=C4CC[C@@H]23)C)C)O
InChI InChI=1S/C22H30O3/c1-13(23)20(25)22(3)11-9-19-18-6-4-14-12-15(24)5-7-16(14)17(18)8-10-21(19,22)2/h12-13,18-19,23H,4-11H2,1-3H3/t13-,18+,19-,21-,22+/m0/s1 Key:JUNDJWOLDSCTFK-MTZCLOFQSA-N

Trimegestone (INN) (brand name Ondeva), also known as 21-hydroxypromegestone, is a 19-norprogesterone derivative and steroidal progestin which was introduced in France in 2001 and is used as a hormonal contraceptive and in hormonal replacement therapy for postmenopausal symptoms.^[1][2][3][4] It is a very potent and pure progestogen, lacking activity at other steroid hormone receptors.^[2][3] Trimegestone has been described as both "fourth generation" and "second generation" (due to the use of different progestin generational schemes; in any case, it is considered to be of the most recent generation).^[5][6]

See also

• Demegestone
• Promegestone

References

1. C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 2063–. ISBN 978-0-412-46630-4.
2. Eckhard Ottow; Hilmar Weinmann (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 208–. ISBN 978-3-527-62330-3.
3. Winnifred Cutler (30 March 2009). Hormones and Your Health: The Smart Woman's Guide to Hormonal and Alternative Therapies for Menopause. John Wiley & Sons. pp. 43–. ISBN 978-0-470-52553-1.
4. Annual Reports in Medicinal Chemistry. Academic Press. 31 December 2012. pp. 273,647. ISBN 978-0-12-397214-9.
5. Ramesh N. Patel (26 September 2006). Biocatalysis in the Pharmaceutical and Biotechnology Industries. CRC Press. pp. 288–. ISBN 978-1-4200-1937-7.
6. Sitruk-Ware R (2004). "New progestogens: a review of their effects in perimenopausal and postmenopausal women". Drugs Aging 21 (13): 865–83. doi:10.2165/00002512-200421130-00004. PMID 15493951.