Mestanolone

Mestanolone

Systematic (IUPAC) name
(5α,17β)-17-hydroxy-17-methylandrostan-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	US: X (Contraindicated)
Routes of administration	Oral
Legal status	DEA Schedule III (US)
Pharmacokinetic data
Bioavailability	99% oral
Protein binding	yes
Metabolism	Hepatic
Biological half-life	?
Excretion	Renal
Identifiers
CAS Number	521-11-9
ATC code	none
PubChem	CID 10633
ChemSpider	10187
UNII	S712YZ168E
KEGG	D01533
ChEMBL	CHEMBL261514
Synonyms	(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Chemical data
Formula	C20H32O2
Molar mass	304.467 g/mol
SMILES O=C2C[C@@H]1CC[C@@H]3[C@@H]([C@@]1(C)CC2)CC[C@]4([C@H]3CC[C@@]4(O)C)C
InChI InChI=1S/C20H32O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h13,15-17,22H,4-12H2,1-3H3/t13-,15+,16-,17-,18-,19-,20-/m0/s1 Key:WYZDXEKUWRCKOB-YDSAWKJFSA-N
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Mestanolone is the 17α-methylated version of dihydrotestosterone (DHT).^[1] The systematic name of mestanolone is: 17β-hydroxy-17α-methylandrost-3-one.^[2] It is an orally bioavailable androgenic steroid that is highly androgenic while only slightly anabolic. It is incapable of aromatization and is not an agonist of the progesterone receptor.

Dosage Information

Dosages range from 10 mg to 30 mg a day for males. Women should avoid Mestanolone for it is very androgenic. Long term use, more than 12 weeks should be avoided do to hepatoxicity. Since Mestanolone is unable to convert to estrogen, it is very useful during cutting phases or when one wishes to avoid excess weight gain.

References

1. CTD (2007). "Chemicals: mestanolone". CTD - Comparative Toxicogenomics Database. Retrieved September 3, 2007.
2. Biology Online.org (2007). "mestanolone". Biology Online.org. Retrieved September 3, 2007.