Topilutamide

Topilutamide

Systematic (IUPAC) name
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide
Clinical data
Trade names	Eucapil
Routes of administration	Topical
Identifiers
CAS Number	260980-89-0
PubChem	CID 44147451
ChemSpider	8106619
Chemical data
Formula	C13H11F6N3O5
Molar mass	403.233959 g/mol
SMILES CC(CNC(=O)C(F)(F)F)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O
InChI InChI=1S/C13H11F6N3O5/c1-11(25,5-20-10(24)13(17,18)19)9(23)21-6-2-3-8(22(26)27)7(4-6)12(14,15)16/h2-4,25H,5H2,1H3,(H,20,24)(H,21,23)/t11-/m1/s1 Key:YCNCRLKXSLARFT-LLVKDONJSA-N

Topilutamide (INN), known more commonly as fluridil (brand name Eucapil), is a topical non-steroidal antiandrogen marketed by Interpharma Praha which is used in a number of European countries in the treatment of androgenic alopecia.^{[1][2][3][4][5]} Sold as Eucapil, it is available as a 2% topical formulation intended for application to the scalp.^[4]

See also

• Bicalutamide
• Alfatradiol
• Spironolactone
• Finasteride

References

1. Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M (2002). "Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience". Dermatol Surg 28 (8): 678–85. doi:10.1046/j.1524-4725.2002.02017.x. PMID 12174057.
2. Robert S. Haber; Dowling Bluford Stough (2006). Hair Transplantation. Elsevier Health Sciences. pp. 7–. ISBN 1-4160-3104-9.
3. Scripta Medica. 2006. pp. 45, 53–54.
4. Marc R. Avram; Nicole E. Rogers (30 November 2009). Hair Transplantation. Cambridge University Press. pp. 11–. ISBN 978-1-139-48339-1.
5. Roger S. Kirby; Culley C. Carson; Michael G. Kirby; Alan White (29 January 2009). Men's Health, Third Edition. CRC Press. pp. 362–. ISBN 978-1-4398-0807-8. Cite uses deprecated parameter |coauthors= (help)