| No. |
R |
Date |
Score |
Opponent |
Record |
| 1 | W | October 11, 1980 | 9–3 | Hartford Whalers (1980–81) | 1–0–0 |
| 2 | W | October 15, 1980 | 3–2 | Boston Bruins (1980–81) | 2–0–0 |
| 3 | T | October 17, 1980 | 5–5 | @ Colorado Rockies (1980–81) | 2–0–1 |
| 4 | L | October 18, 1980 | 2–6 | @ Calgary Flames (1980–81) | 2–1–1 |
| 5 | W | October 22, 1980 | 4–2 | Quebec Nordiques (1980–81) | 3–1–1 |
| 6 | W | October 24, 1980 | 4–2 | @ Edmonton Oilers (1980–81) | 4–1–1 |
| 7 | W | October 25, 1980 | 4–1 | Winnipeg Jets (1980–81) | 5–1–1 |
| 8 | T | October 29, 1980 | 2–2 | St. Louis Blues (1980–81) | 5–1–2 |
| 9 | W | November 1, 1980 | 6–3 | Pittsburgh Penguins (1980–81) | 6–1–2 |
| 10 | W | November 2, 1980 | 8–3 | Calgary Flames (1980–81) | 7–1–2 |
| 11 | L | November 7, 1980 | 2–3 | @ Vancouver Canucks (1980–81) | 7–2–2 |
| 12 | W | November 9, 1980 | 7–1 | @ Chicago Black Hawks (1980–81) | 8–2–2 |
| 13 | T | November 11, 1980 | 6–6 | @ New York Islanders (1980–81) | 8–2–3 |
| 14 | W | November 12, 1980 | 5–1 | @ Hartford Whalers (1980–81) | 9–2–3 |
| 15 | W | November 15, 1980 | 5–2 | Chicago Black Hawks (1980–81) | 10–2–3 |
| 16 | L | November 17, 1980 | 1–2 | New York Islanders (1980–81) | 10–3–3 |
| 17 | W | November 19, 1980 | 3–2 | @ Pittsburgh Penguins (1980–81) | 11–3–3 |
| 18 | T | November 20, 1980 | 1–1 | @ Philadelphia Flyers (1980–81) | 11–3–4 |
| 19 | L | November 22, 1980 | 2–6 | Chicago Black Hawks (1980–81) | 11–4–4 |
| 20 | L | November 26, 1980 | 2–5 | @ Quebec Nordiques (1980–81) | 11–5–4 |
| 21 | W | November 29, 1980 | 4–2 | @ Montreal Canadiens (1980–81) | 12–5–4 |
| 22 | W | December 1, 1980 | 5–3 | @ New York Rangers (1980–81) | 13–5–4 |
| 23 | T | December 3, 1980 | 3–3 | @ Washington Capitals (1980–81) | 13–5–5 |
| 24 | T | December 6, 1980 | 3–3 | Buffalo Sabres (1980–81) | 13–5–6 |
| 25 | T | December 7, 1980 | 1–1 | Detroit Red Wings (1980–81) | 13–5–7 |
| 26 | L | December 9, 1980 | 1–4 | @ St. Louis Blues (1980–81) | 13–6–7 |
| 27 | L | December 10, 1980 | 2–7 | Los Angeles Kings (1980–81) | 13–7–7 |
| 28 | W | December 13, 1980 | 4–3 | Winnipeg Jets (1980–81) | 14–7–7 |
| 29 | L | December 15, 1980 | 3–6 | Toronto Maple Leafs (1980–81) | 14–8–7 |
| 30 | L | December 17, 1980 | 2–4 | @ Toronto Maple Leafs (1980–81) | 14–9–7 |
| 31 | T | December 20, 1980 | 3–3 | New York Rangers (1980–81) | 14–9–8 |
| 32 | W | December 23, 1980 | 6–2 | @ Detroit Red Wings (1980–81) | 15–9–8 |
| 33 | W | December 26, 1980 | 5–3 | @ Winnipeg Jets (1980–81) | 16–9–8 |
| 34 | W | December 27, 1980 | 6–4 | Colorado Rockies (1980–81) | 17–9–8 |
| 35 | W | December 30, 1980 | 6–5 | Philadelphia Flyers (1980–81) | 18–9–8 |
| 36 | W | January 3, 1981 | 3–0 | Washington Capitals (1980–81) | 19–9–8 |
| 37 | T | January 4, 1981 | 2–2 | @ Buffalo Sabres (1980–81) | 19–9–9 |
| 38 | T | January 7, 1981 | 1–1 | Vancouver Canucks (1980–81) | 19–9–10 |
| 39 | L | January 9, 1981 | 2–4 | @ Colorado Rockies (1980–81) | 19–10–10 |
| 40 | W | January 10, 1981 | 3–2 | Washington Capitals (1980–81) | 20–10–10 |
| 41 | L | January 12, 1981 | 3–4 | @ Boston Bruins (1980–81) | 20–11–10 |
| 42 | T | January 14, 1981 | 1–1 | @ Buffalo Sabres (1980–81) | 20–11–11 |
| 43 | W | January 17, 1981 | 7–1 | Quebec Nordiques (1980–81) | 21–11–11 |
| 44 | W | January 19, 1981 | 6–3 | Montreal Canadiens (1980–81) | 22–11–11 |
| 45 | W | January 21, 1981 | 2–1 | @ Washington Capitals (1980–81) | 23–11–11 |
| 46 | L | January 22, 1981 | 4–5 | @ Philadelphia Flyers (1980–81) | 23–12–11 |
| 47 | W | January 24, 1981 | 6–1 | Edmonton Oilers (1980–81) | 24–12–11 |
| 48 | W | January 26, 1981 | 3–2 | Calgary Flames (1980–81) | 25–12–11 |
| 49 | L | January 28, 1981 | 1–3 | @ Pittsburgh Penguins (1980–81) | 25–13–11 |
| 50 | T | January 29, 1981 | 3–3 | @ Detroit Red Wings (1980–81) | 25–13–12 |
| 51 | L | January 31, 1981 | 3–7 | New York Rangers (1980–81) | 25–14–12 |
| 52 | L | February 4, 1981 | 2–6 | @ Quebec Nordiques (1980–81) | 25–15–12 |
| 53 | L | February 5, 1981 | 0–7 | @ Montreal Canadiens (1980–81) | 25–16–12 |
| 54 | T | February 7, 1981 | 5–5 | @ New York Islanders (1980–81) | 25–16–13 |
| 55 | T | February 8, 1981 | 3–3 | @ New York Rangers (1980–81) | 25–16–14 |
| 56 | L | February 12, 1981 | 3–4 | Toronto Maple Leafs (1980–81) | 25–17–14 |
| 57 | W | February 14, 1981 | 7–4 | Hartford Whalers (1980–81) | 26–17–14 |
| 58 | W | February 15, 1981 | 7–2 | Vancouver Canucks (1980–81) | 27–17–14 |
| 59 | W | February 18, 1981 | 6–2 | Colorado Rockies (1980–81) | 28–17–14 |
| 60 | W | February 20, 1981 | 5–3 | @ Winnipeg Jets (1980–81) | 29–17–14 |
| 61 | L | February 21, 1981 | 3–5 | @ Toronto Maple Leafs (1980–81) | 29–18–14 |
| 62 | L | February 23, 1981 | 1–4 | New York Islanders (1980–81) | 29–19–14 |
| 63 | L | February 25, 1981 | 2–3 | @ Hartford Whalers (1980–81) | 29–20–14 |
| 64 | L | February 26, 1981 | 1–5 | @ Boston Bruins (1980–81) | 29–21–14 |
| 65 | L | February 28, 1981 | 2–4 | Philadelphia Flyers (1980–81) | 29–22–14 |
| 66 | T | March 4, 1981 | 3–3 | Boston Bruins (1980–81) | 29–22–15 |
| 67 | W | March 7, 1981 | 8–5 | Pittsburgh Penguins (1980–81) | 30–22–15 |
| 68 | T | March 9, 1981 | 1–1 | Montreal Canadiens (1980–81) | 30–22–16 |
| 69 | W | March 11, 1981 | 3–1 | Buffalo Sabres (1980–81) | 31–22–16 |
| 70 | L | March 12, 1981 | 3–6 | @ Calgary Flames (1980–81) | 31–23–16 |
| 71 | L | March 14, 1981 | 4–10 | @ Los Angeles Kings (1980–81) | 31–24–16 |
| 72 | L | March 18, 1981 | 3–5 | Edmonton Oilers (1980–81) | 31–25–16 |
| 73 | T | March 20, 1981 | 1–1 | @ Edmonton Oilers (1980–81) | 31–25–17 |
| 74 | W | March 22, 1981 | 9–3 | Detroit Red Wings (1980–81) | 32–25–17 |
| 75 | L | March 24, 1981 | 3–4 | Los Angeles Kings (1980–81) | 32–26–17 |
| 76 | L | March 28, 1981 | 2–3 | @ Los Angeles Kings (1980–81) | 32–27–17 |
| 77 | W | March 29, 1981 | 4–2 | @ Vancouver Canucks (1980–81) | 33–27–17 |
| 78 | W | March 31, 1981 | 6–3 | St. Louis Blues (1980–81) | 34–27–17 |
| 79 | W | April 4, 1981 | 5–0 | @ St. Louis Blues (1980–81) | 35–27–17 |
| 80 | L | April 5, 1981 | 4–8 | @ Chicago Black Hawks (1980–81) | 35–28–17 |