2,4-dichlorobenzoyl-CoA reductase

2,4-dichlorobenzoyl-CoA reductase
Identifiers
EC number	1.3.1.63
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2,4-dichlorobenzoyl-CoA reductase (EC 1.3.1.63) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoyl-CoA + NADP⁺ + HCl $\rightleftharpoons$ 2,4-dichlorobenzoyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are 4-chlorobenzoyl-CoA, NADP⁺, and HCl, whereas its 3 products are 2,4-dichlorobenzoyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating). This enzyme participates in 2,4-dichlorobenzoate degradation.

References

• Romanov V, Hausinger RP (1996). "NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A". J. Bacteriol. 178 (9): 2656–61. PMC 177992. PMID 8626335.