2'''-acetyl-6'''-hydroxyneomycin C deacetylase
2'''-acetyl-6'''-hydroxyneomycin C deacetylase (EC 3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).[1] This enzyme catalyses the following chemical reaction
- 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O
6'''-deamino-6'''-hydroxyneomycin C + acetate
This enzyme is involved in biosynthesys of aminoglycoside antibiotics of the [neomycin] family.
References
- ↑ Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. (2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9: 865–869. doi:10.1002/cbic.200700717. PMID 18311744.
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