2-Amino-4-deoxychorismate dehydrogenase
2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.99.24, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- (2S)-2-amino-4-deoxychorismate + FMN
3-(1-carboxyvinyloxy)anthranilate + FMNH2
This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].
References
- ↑ Van Lanen, S.G., Lin, S. and Shen, B. (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proc. Natl. Acad. Sci. USA 105: 494–499. doi:10.1073/pnas.0708750105. PMC 2206564. PMID 18182490.
- ↑ Yu, L., Mah, S., Otani, T. and Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117: 8877–8878. doi:10.1021/ja00139a032.
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