2-Amino-4-deoxychorismate dehydrogenase

2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.99.24, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.^[1]^[2] This enzyme catalyses the following chemical reaction

(2S)-2-amino-4-deoxychorismate + FMN

\rightleftharpoons

3-(1-carboxyvinyloxy)anthranilate + FMNH2

This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].

References

↑ Van Lanen, S.G., Lin, S. and Shen, B. (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proc. Natl. Acad. Sci. USA 105: 494–499. doi:10.1073/pnas.0708750105. PMC 2206564. PMID 18182490.
↑ Yu, L., Mah, S., Otani, T. and Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117: 8877–8878. doi:10.1021/ja00139a032.

External links

2-amino-4-deoxychorismate dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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