2-hydroxy-1,4-benzoquinone reductase

2-hydroxy-1,4-benzoquinone reductase
Identifiers
EC number	1.6.5.7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-hydroxy-1,4-benzoquinone reductase (EC 1.6.5.7) is an enzyme that catalyzes the chemical reaction

2-hydroxy-1,4-benzoquinone + NADH + H⁺ $\rightleftharpoons$ 1,2,4-trihydroxybenzene + NAD⁺

The 3 substrates of this enzyme are 2-hydroxy-1,4-benzoquinone, NADH, and H⁺, whereas its two products are 1,2,4-trihydroxybenzene and NAD⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is 2-hydroxy-1,4-benzoquinone:NADH oxidoreductase. Other names in common use include hydroxybenzoquinone reductase, 1,2,4-trihydroxybenzene:NAD oxidoreductase, and NADH:2-hydroxy-1,4-benzoquinone oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation.

References

• Chakrabarty AM; Daubaras, DL; Zago, A; Xun, L; Saido, K; Klem, T; Nikolic, D; Chakrabarty, AM (1998). "Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100". J. Bacteriol. 180 (17): 4667–75. PMC 107482. PMID 9721310.