| Regular season schedule | 
| No. | R | Date | Score | Opponent | Record | 
 
| 1 | W | October 6, 2000 | 3–1 | Minnesota Wild (2000–01) | 1–0–0–0 | 
| 2 | L | October 8, 2000 | 1–5 | St. Louis Blues (2000–01) | 1–1–0–0 | 
| 3 | L | October 11, 2000 | 2–3 OT | Boston Bruins (2000–01) | 1–1–0–1 | 
| 4 | L | October 14, 2000 | 2–4 | @ New Jersey Devils (2000–01) | 1–2–0–1 | 
 
| 5 | W | October 16, 2000 | 4–3 | @ New York Rangers (2000–01) | 2–2–0–1 | 
 
| 6 | W | October 17, 2000 | 4–3 | @ New York Islanders (2000–01) | 3–2–0–1 | 
 
| 7 | T | October 20, 2000 | 2–2 OT | @ Buffalo Sabres (2000–01) | 3–2–1–1 | 
 
| 8 | W | October 21, 2000 | 4–3 | @ Philadelphia Flyers (2000–01) | 4–2–1–1 | 
| 9 | L | October 23, 2000 | 4–5 OT | Los Angeles Kings (2000–01) | 4–2–1–2 | 
| 10 | L | October 25, 2000 | 2–6 | @ Los Angeles Kings (2000–01) | 4–3–1–2 | 
 
| 11 | W | October 27, 2000 | 3–2 | Edmonton Oilers (2000–01) | 5–3–1–2 | 
 
| 12 | W | October 29, 2000 | 6–3 | @ Calgary Flames (2000–01) | 6–3–1–2 | 
| 13 | L | October 30, 2000 | 3–5 | @ Edmonton Oilers (2000–01) | 6–4–1–2 | 
 
| 14 | T | November 1, 2000 | 1–1 OT | Phoenix Coyotes (2000–01) | 6–4–2–2 | 
 
| 15 | T | November 4, 2000 | 3–3 OT | @ Nashville Predators (2000–01) | 6–4–3–2 | 
| 16 | L | November 5, 2000 | 2–4 | @ Chicago Blackhawks (2000–01) | 6–5–3–2 | 
| 17 | L | November 8, 2000 | 2–7 | Vancouver Canucks (2000–01) | 6–6–3–2 | 
| 18 | L | November 11, 2000 | 1–3 | @ Colorado Avalanche (2000–01) | 6–7–3–2 | 
| 19 | L | November 12, 2000 | 2–3 | Detroit Red Wings (2000–01) | 6–8–3–2 | 
| 20 | L | November 15, 2000 | 0–3 | Colorado Avalanche (2000–01) | 6–9–3–2 | 
 
| 21 | W | November 18, 2000 | 6–2 | @ Phoenix Coyotes (2000–01) | 7–9–3–2 | 
 
| 22 | W | November 19, 2000 | 2–1 | New York Islanders (2000–01) | 8–9–3–2 | 
| 23 | L | November 22, 2000 | 2–5 | New Jersey Devils (2000–01) | 8–10–3–2 | 
 
| 24 | T | November 24, 2000 | 2–2 OT | @ Calgary Flames (2000–01) | 8–10–4–2 | 
| 25 | L | November 25, 2000 | 2–3 | @ Edmonton Oilers (2000–01) | 8–11–4–2 | 
| 26 | L | November 28, 2000 | 1–4 | @ Vancouver Canucks (2000–01) | 8–12–4–2 | 
| 27 | L | November 30, 2000 | 2–3 OT | @ San Jose Sharks (2000–01) | 8–12–4–3 | 
 
| 28 | W | December 3, 2000 | 4–0 | Los Angeles Kings (2000–01) | 9–12–4–3 | 
| 29 | L | December 5, 2000 | 0–1 | @ St. Louis Blues (2000–01) | 9–13–4–3 | 
| 30 | L | December 6, 2000 | 2–5 | @ Columbus Blue Jackets (2000–01) | 9–14–4–3 | 
 
| 31 | W | December 8, 2000 | 1–0 OT | @ Minnesota Wild (2000–01) | 10–14–4–3 | 
| 32 | L | December 10, 2000 | 0–1 | Dallas Stars (2000–01) | 10–15–4–3 | 
 
| 33 | W | December 13, 2000 | 5–4 OT | Columbus Blue Jackets (2000–01) | 11–15–4–3 | 
 
| 34 | W | December 15, 2000 | 6–4 | New York Rangers (2000–01) | 12–15–4–3 | 
 
| 35 | W | December 17, 2000 | 3–1 | Tampa Bay Lightning (2000–01) | 13–15–4–3 | 
| 36 | L | December 20, 2000 | 2–4 | Atlanta Thrashers (2000–01) | 13–16–4–3 | 
| 37 | L | December 22, 2000 | 1–2 OT | @ Detroit Red Wings (2000–01) | 13–16–4–4 | 
| 38 | L | December 23, 2000 | 2–5 | @ St. Louis Blues (2000–01) | 13–17–4–4 | 
| 39 | L | December 27, 2000 | 1–3 | @ Dallas Stars (2000–01) | 13–18–4–4 | 
 
| 40 | T | December 28, 2000 | 2–2 OT | @ Nashville Predators (2000–01) | 13–18–5–4 | 
| 41 | L | December 31, 2000 | 2–3 | @ Minnesota Wild (2000–01) | 13–19–5–4 | 
 
| 42 | W | January 3, 2001 | 3–2 OT | Florida Panthers (2000–01) | 14–19–5–4 | 
 
| 43 | T | January 5, 2001 | 4–4 OT | Calgary Flames (2000–01) | 14–19–6–4 | 
| 44 | L | January 10, 2001 | 2–4 | St. Louis Blues (2000–01) | 14–20–6–4 | 
| 45 | L | January 12, 2001 | 0–4 | Buffalo Sabres (2000–01) | 14–21–6–4 | 
| 46 | L | January 14, 2001 | 0–4 | @ Carolina Hurricanes (2000–01) | 14–22–6–4 | 
| 47 | L | January 15, 2001 | 2–3 | @ Pittsburgh Penguins (2000–01) | 14–23–6–4 | 
 
| 48 | W | January 17, 2001 | 5–2 | @ Atlanta Thrashers (2000–01) | 15–23–6–4 | 
| 49 | L | January 19, 2001 | 3–4 | Phoenix Coyotes (2000–01) | 15–24–6–4 | 
| 50 | L | January 21, 2001 | 2–4 | Colorado Avalanche (2000–01) | 15–25–6–4 | 
| 51 | L | January 24, 2001 | 0–5 | Minnesota Wild (2000–01) | 15–26–6–4 | 
| 52 | L | January 26, 2001 | 2–3 | @ Detroit Red Wings (2000–01) | 15–27–6–4 | 
| 53 | L | January 27, 2001 | 1–2 | @ Columbus Blue Jackets (2000–01) | 15–28–6–4 | 
| 54 | L | January 31, 2001 | 0–3 | Nashville Predators (2000–01) | 15–29–6–4 | 
 
| 55 | W | February 1, 2001 | 4–2 | @ Phoenix Coyotes (2000–01) | 16–29–6–4 | 
| 56 | L | February 7, 2001 | 2–3 | Chicago Blackhawks (2000–01) | 16–30–6–4 | 
| 57 | L | February 9, 2001 | 3–4 | Washington Capitals (2000–01) | 16–31–6–4 | 
 
| 58 | T | February 11, 2001 | 2–2 OT | Carolina Hurricanes (2000–01) | 16–31–7–4 | 
 
| 59 | T | February 14, 2001 | 3–3 OT | Edmonton Oilers (2000–01) | 16–31–8–4 | 
| 60 | L | February 16, 2001 | 2–3 OT | @ Dallas Stars (2000–01) | 16–31–8–5 | 
 
| 61 | W | February 19, 2001 | 6–2 | Calgary Flames (2000–01) | 17–31–8–5 | 
 
| 62 | W | February 21, 2001 | 1–0 | San Jose Sharks (2000–01) | 18–31–8–5 | 
| 63 | L | February 23, 2001 | 1–3 | @ San Jose Sharks (2000–01) | 18–32–8–5 | 
| 64 | L | February 25, 2001 | 2–5 | Columbus Blue Jackets (2000–01) | 18–33–8–5 | 
| 65 | L | February 28, 2001 | 1–3 | Detroit Red Wings (2000–01) | 18–34–8–5 | 
| 66 | L | March 2, 2001 | 2–5 | Dallas Stars (2000–01) | 18–35–8–5 | 
 
| 67 | W | March 4, 2001 | 4–0 | Los Angeles Kings (2000–01) | 19–35–8–5 | 
 
| 68 | W | March 7, 2001 | 4–2 | Montreal Canadiens (2000–01) | 20–35–8–5 | 
 
| 69 | W | March 9, 2001 | 3–1 | Chicago Blackhawks (2000–01) | 21–35–8–5 | 
 
| 70 | W | March 11, 2001 | 1–0 OT | Nashville Predators (2000–01) | 22–35–8–5 | 
 
| 71 | W | March 13, 2001 | 2–0 | @ Washington Capitals (2000–01) | 23–35–8–5 | 
| 72 | L | March 14, 2001 | 2–3 | @ Toronto Maple Leafs (2000–01) | 23–36–8–5 | 
| 73 | L | March 16, 2001 | 1–4 | @ Ottawa Senators (2000–01) | 23–37–8–5 | 
 
| 74 | W | March 18, 2001 | 4–1 | @ Chicago Blackhawks (2000–01) | 24–37–8–5 | 
| 75 | L | March 21, 2001 | 0–8 | @ Dallas Stars (2000–01) | 24–38–8–5 | 
 
| 76 | T | March 24, 2001 | 3–3 OT | @ Los Angeles Kings (2000–01) | 24–38–9–5 | 
| 77 | L | March 29, 2001 | 4–7 | @ San Jose Sharks (2000–01) | 24–39–9–5 | 
 
| 78 | T | March 30, 2001 | 2–2 OT | @ Vancouver Canucks (2000–01) | 24–39–10–5 | 
 
| 79 | W | April 1, 2001 | 2–1 | Vancouver Canucks (2000–01) | 25–39–10–5 | 
 
| 80 | T | April 4, 2001 | 1–1 OT | @ Colorado Avalanche (2000–01) | 25–39–11–5 | 
| 81 | L | April 6, 2001 | 2–5 | Phoenix Coyotes (2000–01) | 25–40–11–5 | 
| 82 | L | April 8, 2001 | 1–4 | San Jose Sharks (2000–01) | 25–41–11–5 |