3,4-dihydroxyphenylalanine reductive deaminase

3,4-dihydroxyphenylalanine reductive deaminase (EC 4.3.1.22, reductive deaminase, DOPA-reductive deaminase, DOPARDA) is an enzyme with systematic name 3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming).^[1] This enzyme catalyses the following chemical reaction

L-dopa + 2 NADH

\rightleftharpoons

3,4-dihydroxyphenylpropanoate + 2 NAD⁺ + NH₃

This enzyme participates in the L-phenylalanine-catabolism in the anaerobic phototrophic bacterium Rhodobacter sphaeroides OU5.

References

↑ Ranjith, N.K., Sasikala, Ch. and Ramana, Ch.V. (2007). "Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine". Res. Microbiol. 158: 506–511. doi:10.1016/j.resmic.2007.04.008. PMID 17616348.

External links

3,4-dihydroxyphenylalanine reductive deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-nitrogen lyases (EC 4.3)

4.3.1: ammonia-lyases	Histidine ammonia-lyase Formiminotransferase cyclodeaminase Serine dehydratase

4.3.2: amidine-lyases	Argininosuccinate lyase Adenylosuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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