3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Identifiers
EC number 1.14.14.12
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 \rightleftharpoons 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.

References

  1. Dresen, C., Lin, L.Y., D'Angelo, I., Tocheva, E.I., Strynadka, N. and Eltis, L.D. (2010). "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism". J. Biol. Chem. 285 (29): 22264–22275. doi:10.1074/jbc.M109.099028. PMC 2903365. PMID 20448045.

External links

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