3-hydroxybutyryl-CoA epimerase

3-hydroxybutyryl-CoA epimerase
Identifiers
EC number	5.1.2.3
CAS number	9024-21-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA $\rightleftharpoons$ (R)-3-hydroxybutanoyl-CoA

Hence, this enzyme has one substrate, (S)-3-hydroxybutanoyl-CoA, and one product, (R)-3-hydroxybutanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. The systematic name of this enzyme class is 3-hydroxybutanoyl-CoA 3-epimerase. Other names in common use include 3-hydroxybutyryl coenzyme A epimerase, and 3-hydroxyacyl-CoA epimerase. This enzyme participates in fatty acid metabolism and butanoate metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1WDK, 1WDL, 1WDM, and 2D3T.

References

• Stern JR, del Campillo A and Lehninger AL (1955). "Enzymatic racemization of beta-hydroxybutyryl-S-CoA and the stereospecificity of enzymes of the fatty acid cycle". J. Am. Chem. Soc. 77 (4): 1073–1074. doi:10.1021/ja01609a105.
• Wakil SJ (1955). "D(-)beta-Hydroxybutyryl CoA dehydrogenase". Biochim. Biophys. Acta 18 (2): 314–315. doi:10.1016/0006-3002(55)90089-5. PMID 13276396.