3-hydroxyindolin-2-one monooxygenase

3-hydroxyindolin-2-one monooxygenase
Identifiers
EC number	1.14.13.139
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

3-hydroxyindolin-2-one monooxygenase (EC 1.14.13.139, BX4 (gene), CYP71C1 (gene)) is an enzyme with systematic name 3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

3-hydroxyindolin-2-one + NAD(P)H + H⁺ + O₂ $\rightleftharpoons$ 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)⁺ + H₂O

3-hydroxyindolin-2-one monooxygenase is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants.

References

1. Glawischnig, E., Grun, S., Frey, M. and Gierl, A. (1999). "Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses". Phytochemistry 50 (6): 925–930. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.
2. Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. (1997). "Analysis of a chemical plant defense mechanism in grasses". Science 277 (5326): 696–699. doi:10.1126/science.277.5326.696. PMID 9235894.
3. Spiteller, P., Glawischnig, E., Gierl, A. and Steglich, W. (2001). "Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays". Phytochemistry 57 (3): 373–376. doi:10.1016/s0031-9422(01)00037-1. PMID 11393516.

External links

• 3-hydroxyindolin-2-one monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)