4-acetamidobutyryl-CoA deacetylase

4-acetamidobutyryl-CoA deacetylase
Identifiers
EC number	3.5.1.51
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-acetamidobutyryl-CoA deacetylase (EC 3.5.1.51) is an enzyme that catalyzes the chemical reaction

4-acetamidobutanoyl-CoA + H₂O $\rightleftharpoons$ acetate + 4-aminobutanoyl-CoA

Thus, the two substrates of this enzyme are 4-acetamidobutanoyl-CoA and H₂O, whereas its two products are acetate and 4-aminobutanoyl-CoA.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-acetamidobutanoyl-CoA amidohydrolase. Other names in common use include aminobutyryl-CoA thiolesterase, and deacetylase-thiolesterase.

References

• Ohsugi M, Kahn J, Hensley C, Chew S, Barker HA (1981). "Metabolism of L-beta-lysine by a Pseudomonas. Purification and properties of a deacetylase-thiolesterase utilizing 4-acetamidobutyryl CoA and related compounds". J. Biol. Chem. 256 (14): 7642–51. PMID 6788773.