4-Hydroxybenzoate geranyltransferase

4-hydroxybenzoate geranyltransferase (EC 2.5.1.93, PGT1, PGT2, 4HB geranyltransferase, 4HB:geranyltransferase, p-hydroxybenzoate geranyltransferase, PHB geranyltransferase, geranyl diphosphate:4-hydroxybenzoate geranyltransferase) is an enzyme with systematic name geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

geranyl diphosphate + 4-hydroxybenzoate

\rightleftharpoons

3-geranyl-4-hydroxybenzoate + diphosphate

The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg²⁺.

References

↑ Ohara, K., Muroya, A., Fukushima, N. and Yazaki, K. (2009). "Functional characterization of LePGT₁, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid". Biochem. J. 421: 231–241. doi:10.1042/bj20081968. PMID 19392660.
↑ Muhlenweg, A., Melzer, M., Li, S.M. and Heide, L. (1998). "4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase". Planta 205: 407–413. doi:10.1007/s004250050337. PMID 9640665.
↑ Yazaki, K., Kunihisa, M., Fujisaki, T. and Sato, F. (2002). "Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a key enzyme in shikonin biosynthesis". J. Biol. Chem. 277: 6240–6246. doi:10.1074/jbc.m106387200. PMID 11744717.

External links

4-hydroxybenzoate geranyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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