4-hydroxybenzoyl-CoA reductase

4-hydroxybenzoyl-CoA reductase
Identifiers
EC number	1.3.7.9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.7.9) is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction^[1][2]

benzoyl-CoA + acceptor + H₂O $\rightleftharpoons$ 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H₂O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme participates in benzoate degradation via coa ligation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:

• 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
• 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.

References

1. Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS Lett. 251 (1-2): 237–40. doi:10.1016/0014-5793(89)81461-9. PMID 2753161.
2. Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G (August 1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. doi:10.1007/s002030050623. PMID 9683649.

Further reading

• Breese K, Fuchs G (1998). "4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins". Eur. J. Biochem. 251 (3): 916–23. doi:10.1046/j.1432-1327.1998.2510916.x. PMID 9490068.
• Brackmann R, Fuchs G (1993). "Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species". Eur. J. Biochem. 213 (1): 563–71. doi:10.1111/j.1432-1033.1993.tb17795.x. PMID 8477729.
• Heider J, Fuchs G (1997). "Anaerobic metabolism of aromatic compounds". Eur. J. Biochem. 243 (3): 577–96. doi:10.1111/j.1432-1033.1997.00577.x. PMID 9057820.