5-hydroxyfuranocoumarin 5-O-methyltransferase

5-hydroxyfuranocoumarin 5-O-methyltransferase
Identifiers
EC number	2.1.1.69
CAS number	101637-31-4&title= 67339-12-2, 101637-31-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

5-hydroxyfuranocoumarin 5-O-methyltransferase (EC 2.1.1.69, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin $\rightleftharpoons$ S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction)

(2) S-adenosyl-L-methionine + bergaptol $\rightleftharpoons$ S-adenosyl-L-homocysteine + bergapten

The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin.

References

1. Thompson, H.J., Sharma, S.K. and Brown, S.A. (1978). "O-Methyltransferases of furanocoumarin biosynthesis". Arch. Biochem. Biophys. 188: 272–281. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
2. Sharma, S.K., Garrett, J.M. and Brown, S.A. (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Z. Naturforsch. C 34C: 387–391. PMID 156999.
3. Hauffe, K.D., Hahlbrock, K. and Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Z. Naturforsch. C: Biosci. 41: 228–239.
4. Hehmann, M., Lukačin, R., Ekiert, H. and Matern, U. (2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". Eur. J. Biochem. 271: 932–940. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.

External links

• 5-hydroxyfuranocoumarin 5-O-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)