6-Hydroxy-3-succinoylpyridine 3-monooxygenase

6-hydroxy-3-succinoylpyridine 3-monooxygenase
Identifiers
EC number	1.14.13.163
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

6-hydroxy-3-succinoylpyridine 3-monooxygenase (EC 1.14.13.163, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing).^[1][2] This enzyme catalyses the following chemical reaction

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H⁺ + O₂ $\rightleftharpoons$ 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD⁺ + H₂O

6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.

References

1. Tang, H., Wang, S., Ma, L., Meng, X., Deng, Z., Zhang, D., Ma, C. and Xu, P. (2008). "A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16". Appl. Environ. Microbiol. 74 (5): 1567–1574. doi:10.1128/AEM.02529-07. PMC 2258644. PMID 18203859.
2. Tang, H., Yao, Y., Zhang, D., Meng, X., Wang, L., Yu, H., Ma, L. and Xu, P. (2011). "A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida". J. Biol. Chem. 286 (45): 39179–39187. doi:10.1074/jbc.M111.283929. PMC 3234743. PMID 21949128.

External links

• 6-hydroxy-3-succinoylpyridine 3-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)