6β-Hydroxyhyoscyamine epoxidase
| 6β-Hydroxyhyoscyamine epoxidase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.14.11.14 | ||||||||
| CAS number | 121479-53-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a 6β-hydroxyhyoscyamine epoxidase (EC 1.14.11.14) is an enzyme that catalyzes the chemical reaction
- (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2
scopolamine + succinate + CO2 + H2O
The 3 substrates of this enzyme are (6S)-6-hydroxyhyoscyamine, 2-oxoglutarate, and O2, whereas its 4 products are scopolamine, succinate, CO2, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor. This enzyme participates in alkaloid biosynthesis ii. It has two cofactors: iron and ascorbate.
Nomenclature
The systematic name of this enzyme class is (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming). This enzyme is also called hydroxyhyoscyamine dioxygenase.
References
- Hashimoto T, Kohno J and Yamada Y (1989). "6β-Hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger". Phytochemistry 28 (4): 1077–1082. doi:10.1016/0031-9422(89)80186-4.
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