8-hydroxyfuranocoumarin 8-O-methyltransferase

8-hydroxyfuranocoumarin 8-O-methyltransferase
Identifiers
EC number 2.1.1.70
CAS number 67339-13-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin \rightleftharpoons S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)
(2) S-adenosyl-L-methionine + xanthotoxol \rightleftharpoons S-adenosyl-L-homocysteine + xanthotoxin

8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol into xanthotoxin.

References

  1. Thompson, H.J., Sharma, S.K. and Brown, S.A. (1978). "O-Methyltransferases of furanocoumarin biosynthesis". Arch. Biochem. Biophys. 188: 272–281. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
  2. Hauffe, K.D., Hahlbrock, K. and Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Z. Naturforsch. C 41: 228–239.
  3. Sharma, S.K., Garrett, J.M. and Brown, S.A. (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Z. Naturforsch. C 34C: 387–391. PMID 156999.
  4. Hehmann, M., Lukačin, R., Ekiert, H. and Matern, U. (2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". Eur. J. Biochem. 271: 932–940. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.

External links

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