A-971432

A-971432

Ball and stick structure of A-971432
Systematic (IUPAC) name
1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid
Identifiers
CAS Number	1240308-45-5
PubChem	CID 46872626
ChemSpider	35523147
Chemical data
Formula	C18H17Cl2NO3
Molar mass	366.238 g/mol
SMILES C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O
InChI InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23) Key:WAAWETUDFSIYSD-UHFFFAOYSA-N
(what is this?)

A-971432 is an orally bioavailable selective agonist of Sphingosine-1-phosphate receptor 5 S1PR5 discovered^[1] at AbbVie. It was discovered using High-Throughput chemistry.^[2] S1P5 agonists have been proposed as an innovative mechanism for the treatment of neurodegenerative disorders such as Alzheimer's disease and lysosomal storage disorders such as Niemann–Pick disease.^[3] A-971432 is available commercially from CreaGen Biosciences. It is also available from the AbbVie Compound Toolbox.

See also

• S1PR5
• Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)^[4]

References

1. WO application 2010093704, AbbVie, "Preparation of 1-benzylazetidine-3-carboxylic acid derivatives as agonists and antagonists of the S1P5 receptor", published 2010-08-19 
2. Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
3. Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. doi:10.1016/j.jalz.2014.07.153.
4. Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. PMID 23541049.