S1PR5

Sphingosine-1-phosphate receptor 5
Identifiers
Symbols S1PR5 ; EDG8; Edg-8; S1P5; SPPR-1; SPPR-2
External IDs OMIM: 605146 MGI: 2150641 HomoloGene: 11031 IUPHAR: 279 ChEMBL: 2274 GeneCards: S1PR5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 53637 94226
Ensembl ENSG00000180739 ENSMUSG00000045087
UniProt Q9H228 Q91X56
RefSeq (mRNA) NM_001166215 NM_053190
RefSeq (protein) NP_001159687 NP_444420
Location (UCSC) Chr 19:
10.51 – 10.52 Mb		 Chr 9:
21.24 – 21.25 Mb
PubMed search

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[1]

Agonists

See also

References

  1. ↑ "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".
  2. ↑ Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
  3. ↑ Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. PMID 23541049.

Further reading

  • Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR (May 2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507. 
  • Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH (Feb 2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896. 
  • Hla T (Apr 2001). "Sphingosine 1-phosphate receptors". Prostaglandins 64 (1-4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101. 
  • Im DS, Clemens J, Macdonald TL, Lynch KR (Nov 2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398. 
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Niedernberg A, Scherer CR, Busch AE, Kostenis E (Oct 2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605. 
  • Kothapalli R, Kusmartseva I, Loughran TP (Dec 2002). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica Et Biophysica Acta 1579 (2-3): 117–23. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546. 
  • Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B (Apr 2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
  • Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. doi:10.1016/j.jalz.2014.07.153. 
  • Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J (Oct 2009). "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med. PMID 19808259. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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